The efficient expansion and persistence of CART cell may in part be attributable to the conditioning chemotherapy, in which nab-paclitaxel may promote HER2 antigen presentation by depleting tumor stroma and cyclophosphamide plays a key role in depleting regulatory T cells (Tregs), myeloid-derived suppressor cell (MDSC) as well as other inhibitory cells, and creating an appropriate “lymphoid space” that is devoid of regulatory mechanisms (Dudley ME et al., 2002). The gene discussed is ERBB2; the disease is neoplasm.