These hubs include genes associated with body-mass index and obesity related traits (GNB1, PPP1CB, RCAN2, RSBN1, PSD3, TOMM20)34, 35; anorexia nervosa (PPP3CA)36; bipolar disorder (MARCKS, BASP-1)37, 38; and schizophrenia (GPM6A)39. This evidence concerns the gene PPP1CB and obesity due to melanocortin 4 receptor deficiency.