In an attempt to evaluate the NF2 mutations relative to tumour behaviours, the detection for the mutation (including exonic deletions) and the copy number of the NF2 gene was performed using a combination of Direct sequencing and MLPA analysis among the two groups with different clinical characteristics, including 38 cases of young patients and 53 cases of elderly patients with sporadic VSs (Fig. 1, also see in Supplementary Table S1). This evidence concerns the gene NF2 and neoplasm.