The tumor expression levels of cyclin D1 and c-Myc, which are major target genes of the Wnt/β-catenin signaling pathway, were comparable between the DEN-treated LIrs1KO and DEN-treated control mice, as well as between the DEN-treated LIrs2KO and DEN-treated control mice (Fig. 4C,E). This evidence concerns the gene MYC and neoplasm.