MTSS1 and cancer: In fact, our in silico analyses of miR-141-3p target genes have revealed that metastasis suppressor 1 (MTSS1) is very likely a potential target of miR-141-3p, as indicated by highly conserved miRNA recognition elements (MREs) at the 3′ UTR of MTSS1. Even though MTSS1 is widely known as a metastasis suppressor gene that is involved in regulation of cell mobility and consequently cancer metastasis44–49, recent studies surprisingly indicated that MTSS1 also acts as an oncogene and a driver of metastasis in melanoma tumours and breast cancers50, 51.