Candidate targets of miR-29s include: oxidative stress sensor PARK7 (DJ-1), Parkin substrate GPR37, targets related to apoptotic processes Puma, Bim, Bak, Bcl2, IGF1 and AKT1, microglial phagocytosis-related CDC42, and the epigenetic molecules DNMT3A, DNMT3B and HDAC4. miR-29a, and miR-29c were recently found to be downregulated in the same patients with idiopathic rapid eye movement behavior disorder after they were diagnosed with PD and dementia with Lewy bodies35. This evidence concerns the gene PRKN and Parkinson disease.