Furthermore, eight co-expression networks in MSigDB performed similar to CINSARC: CCNA2, CCNB2, CDC20, CENPF, MCM4, PCNA, RRM1 and RRM2. These 12 signatures are predominantly enriched in the same tumor types: adrenocortical cancer, medulloblastoma, gastric cancer, Burkitt’s lymphoma, liver cancer, primary liver cancer, melanoma, mesothelioma, pancreatic cancer and Ewing’s sarcoma. The gene discussed is RRM2; the disease is familial pancreatic carcinoma.