However, Tregs only accounted for approximately 10% of the total IL-10+CD4+ T cells in the uninfected mice and slightly more than 15% of the total IL-10+CD4+ T cells in the infected mice, congruous with an infection-dependent increase in IL-10 production by Foxp3+CD4+ T cells (see Supplementary Fig. S2). The gene discussed is FOXP3; the disease is infection.