The development of a closed-loop system that combines glucose monitoring with computer-based algorithm-directed insulin delivery9 may provide further improvements in glycaemic control while reducing hypoglycaemia10 11 and represents an emerging treatment option for people with T1D.12 Closed-loop differs from conventional pump therapy, characterised by preprogrammed basal delivery, through the use of a control algorithm that directs subcutaneous insulin delivery according to sensor glucose levels. The gene discussed is INS; the disease is type 1 diabetes mellitus.