The growth of IH is enhanced by pro-angiogenic factors, including VEGF and basic fibroblast growth factor (bFGF) and propranolol inhibits the growth of IH by decreasing the expression of pro-angiogenic factors and Hypoxia Inducible Factor 1 (HIF-1) induced by adrenergic receptors [26–32]. Here, VEGFA is linked to isolated hemihyperplasia.