To explore the expression of Trop2 in thyroid cancer, we initially investigated the expression of Trop2 in 59 pairs of thyroid tumors and their adjacent non-tumorous thyroid tissues using RNAseqV2 data sets for thyroid cancer deposited on The Cancer Genome Atlas (TCGA, https://cancergenome.nih.gov/) website. This evidence concerns the gene TACSTD2 and thyroid cancer.