CD8A and infection: Strong correlations were also observed between semen HIV-RNA load and the CD4+ cell count (r = -0.98, p<0.0001, adjusted p = 0.001) (Fig 3b), and the CD4/CD8 ratio (r = -0.85, p = 0.008, adjusted p = 0.10) (Fig 3c), while seminal RNA did not correlate with blood RNA and CD4 counts in recent infection.