CYP11B2 and epilepsy: In the NEC filtering of the specific variants, three additional common variants (seen in over five existing rat strain sequences–S2 Table) were found in genes that have been associated with epilepsy and segregate with the two non-seizing F2 rats; Abat (4-aminobutyrate aminotransferase), Cyp11b3 (11-beta-hydroxylase) and Cyp11b2 (aldosterone synthase) [3, 12, 38–44].