As model inhibitors, we used sFRP1 and Dkk1 and as model cells, we used known cell lines that mimic the level of LoF of APC in human cancer cells, both with truncated APC (APC1572T [34]) and with attenuated levels of full-length APC (APCneoR, APCneoF[32]) (see Table 3). The gene discussed is APC; the disease is cancer.