Jerky (also known as JRK or JH8; [118–123]), the human homolog of Ebd, rescues ebd mutant phenotypes when expressed in Drosophila [53] and promotes the aberrant increase of both cell proliferation and β-catenin-TCF mediated transcription in colon cancer cell lines [53,124,125]. Here, HNF4A is linked to colonic neoplasm.