In view of the present results, we conclude that resveratrol recovers glycaemic homeostasis in T2DM mice, and that involves increased Slc2a4/GLUT4 expression in muscle and decreased Slc2a2/GLUT2 expression in the liver, which may be related to increased nuclear SIRT1 content. Here, SIRT1 is linked to type 2 diabetes mellitus.