Finally, lipocalin-2 (LCN2), an adipokine correlated with obesity and IR, has been shown to exacerbate psoriatic skin lesions in mice, through increase of IL-17A/F, IL-23p19, IL-12p40, CCL20 and TNF-α, levels, but not IL-12p35 [105]. The gene discussed is TNF; the disease is obesity due to melanocortin 4 receptor deficiency.