In consideration of ethnic differences, as well as the difference between familial (with germline mutations) versus sporadic patients, we previously screened 33 Chinese non‐familial patients with PSIS for mutations in genes HESX1, LHX4, PROP1, OTX2 and SOX3 genes which were known to associated with familial PSIS 9, 16, 17. The gene discussed is OTX2; the disease is pituitary stalk interruption syndrome.