The S-CTLA-4 mean score in the PTs was, in both stromal and tumor epithelial compartments, extensively correlated with other immunological markers previously analyzed by our group (CD3, CD4, CD8, CD45RO, CD20, PD-1, PD-L1), while T-CTLA-4 in PTs was not (supplementary Table 2) [27, 30–33]. Here, CD8A is linked to neoplasm.