In NSCLC, evidence supports that tumor cells sampled from the PT and metastatic sites display molecularly distinct characteristics; genetic heterogeneity between tumor cells in PTs and LN+ with regard to EGFR (epidermal growth factor receptor) and KRAS (Kirsten ras oncogene homolog) status and mutational profiles of other actionable genes is not infrequent [38, 39]. This evidence concerns the gene EGFR and non-small cell lung carcinoma.