OXR1 and specific language impairment: The role of other TLDc proteins in human disease remains to be elucidated, although a very recent whole-exome sequencing study from families with specific language impairment (SLI) identified an inherited heterozygous mutation that introduces a premature stop codon in the first unique exon of the shortest OXR1 isoform (OXR1-C, Fig. 1) (Chen et al. 2017).