It was also observed that the intermediate TLDc-domain-containing OXR1 isoforms were up-regulated compared to age-matched controls in end-stage post-mortem spinal cord from patients with ALS, as well as a threefold increase in the full-length Oxr1 in spinal cords of pre-symptomatic hSOD1G93A mice (Oliver et al. 2011). The gene discussed is OXR1; the disease is amyotrophic lateral sclerosis.