TBC1D24 and epilepsy: While functional studies have focused on the role of TBC1D24 at the synapse, it must also be considered that TBC1D24 confers neuronal resistance against OS via its TLDc domain (Finelli et al. 2016); for example, epilepsy-associated mutations appear to be detrimental to OS resistance in neurons (Finelli et al. 2016).