Somewhat related results were obtained in the hSOD1G93A ALS model, where a reduction in the expression of several neuroinflammatory and complement activating markers occurred in SOD1 mutants over-expressing Oxr1 (Liu et al. 2015); this in turn led to decreased astrogliosis and microgliosis in spinal cord of hSOD1G93A mice (Liu et al. 2015). Here, SOD1 is linked to amyotrophic lateral sclerosis.