Proinflammatory properties of C5aR2 have been shown in experimental allergic asthma [65, 68], dextran sulfate sodium- (DSS-) induced acute colitis [67], thioglycollate-induced peritonitis and air-pouch inflammation [68], acute lung injury (AKI) [71], acute pyelonephritis [72], renal I/R injury [73], and sepsis [7]. The gene discussed is C5AR2; the disease is acute kidney injury.