In cardiomyocyts (CMs) from CLP-septic C5aR1 and C5aR2 KO mice, both receptors contributed to the cytokine storm that have been linked to cardiosuppression in sepsis, demonstrated by reduced levels of IL-6, TNFα, IL-1β, IL-10, and others [75]. This evidence concerns the gene C5AR1 and Sepsis.