While M1 plays a positive role in destroying foreign organisms and tumor cells, M2 with over-expressed mannose receptors (MRs, CD206) may provoke pathological events such as chronic infections, tumorigenesis, and tumor metastasis.1 The asialoglycoprotein receptors (ASGPrs) are expressed predominantly on hepatocytes for clearance of galactose-terminated glycoproteins. The gene discussed is MRC1; the disease is neoplasm.