A more recent study addressed the contribution of DNMT gene polymorphisms in a large cohort of AITD patients composed by a total of 685 GD patients, 353 HT patients, and 909 healthy controls, revealing that both rs2424913 in DNMT3B and rs2228611 in DNMT1 were associated with AITD susceptibility (27). Here, DNMT1 is linked to hematocrit.