ICAM1 and autoimmune disease: Among them, the authors identified some candidate genes already associated to GD or other autoimmune diseases, such as the immunoregulatory factor ADRB2 (hypermethylated), ICAM1 (hypomethylated) coding for a glycoprotein of cell surface named intercellular adhesion molecule 1, B3GNT2 (hypermethylated) involved in the regulation of lymphocyte activity, and others (31).