However, despite of insulin resistance increases with age, racial health disparities and pubertal status (Ball et al., 2006), some authors have shown in girls and boys from 9 to 16 years an interesting relationship between physical activity and decreases in both insulin and the homeostasis model assessment of insulin resistance (HOMA-IR) marker changes throughout development (Metcalf et al., 2015). The gene discussed is INS; the disease is Insulin resistance.