DET also showed pleiotropic function against lipopolysaccharide/D-galactosamine (LPS/D-GalN)-induced fulminant hepatitis by attenuating proinflammatory macrophage infiltration and cytokines, cyclooxygenase-2 (COX-2), and inducible nitric oxide synthase (iNOS) expression (Huang et al., 2013). This evidence concerns the gene PTGS2 and Fulminant hepatitis.