We have previously found that both DET and/or DETD-35 could significantly induce the generation of ROS in TS/A(ER+) mammary cancer cells, MDA-MB-231 cells or human BRAF mutant A375 melanoma cells (Lee and Shyur, 2012; Feng et al., 2016; Shiau et al., 2017). Here, BRAF is linked to melanoma.