Epidermal growth factor-like repeat and discoidin I-like domain-containing protein 3 (EDIL-3) and lysyl oxidase homolog 2 (LOXL2) were reported to facilitate cancer cell migration and pre-metastatic niche formation which were also down-regulated in the DET or DETD-35 responsive exosomes. The gene discussed is LOXL2; the disease is cancer.