Specifically, the protein expression of laminin subunit alpha-5 and subunit gamma-1, collagen alpha-1(V) chain involved in cell migration, collagen alpha-2(IV) chain, collagen alpha-1(XVIII) chain, lactadherin, and BM-specific heparin sulfate proteoglycan core protein for angiogenesis, and tubulointerstitial nephritis antigen-like, collagen alpha-1(XII) chain, lysyl oxidase homolog 2, epidermal growth factor (EGF)-like repeat and discoidin I-like domain-containing protein 3, and laminin subunit alpha-2 for cell adhesion activity were attenuated. This evidence concerns the gene LAMA2 and interstitial nephritis.