The anti-TS/A cancer cell activity of DET is through ROS/c-Jun N-terminal kinases (JNK)-mediated apoptosis, deregulation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB)/IκB kinase (IKK) pathways and ubiquitin-proteasome machinery, which impedes cancer cell motility by inhibiting calpain-mediated adhesion dynamics, and formation of centrosomal aggregates among others (Huang et al., 2010; Lee et al., 2010; Lee and Shyur, 2012). This evidence concerns the gene MAPK8 and cancer.