RPS6KB1 and Hepatic fibrosis: We observed that several exosomal proteins responsive to DET and DETD-35 treatment are commonly involved in mediation or regulation of eukaryotic initiation factor 2 (EIF2) signaling, eukaryotic initiation factor 4 (eIF4) and p70S6K signaling, mechanistic target of rapamycin (mTOR) signaling, hepatic fibrosis/hepatic stellate cell activation, γ-glutamyl cycle, and glutathione biosynthesis (Figure 6A).