Furthermore, this study included subjects with infertility with or without PCOS, in whom, unfortunately, the main focus of doctors and patients was on infertility problems; our data will encourage doctors and patients to be aware of the high prevalence and role of obesity and insulin resistance first and, second, to correct the endocrine dysfunction in those women with PCOS by reducing their weight and improving their insulin levels. This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.