Growing evidence suggests that various members of CLRs are associated with severe immune mediated diseases like juvenile idiopathic arthritis (JIA)14, type 1 diabetes (T1DM)15, systemic lupus erythematosus (SLE)16, rheumatoid arthritis (RA)17 and multiple sclerosis (MS)18. The gene discussed is LARS1; the disease is juvenile idiopathic arthritis.