We subsequently identified Mg29 mRNA as induced in the hearts of mice following transverse aortic constriction (TAC), myocardial infarction (MI) injury, in transgenic mice expressing activated calcineurin (CnA), and strongly in Csrp3−/− mice lacking muscle LIM protein (MLP), which is a model of dilated cardiomyopathy (Fig. 1a)22. Here, SYPL2 is linked to dilated cardiomyopathy.