In conclusion, T2DM impairs autophagic response to I/R in the kidney via suppression of SIRT1/AMPK/ULK1 signaling and enhancement of mTORC1, and the insufficient activation of autophagy during I/R contributes to aggravation of I/R-induced AKI by T2DM. The gene discussed is SIRT1; the disease is type 2 diabetes mellitus.