Although survival profiles were indistinguishable when either component was manipulated specifically in fat body tissue, differences were seen regarding their effect on the level of Drs transcript; with Ago-1 overexpression, Drs was not induced in response to infection—behaving equivalently to a Toll pathway mutant—whereas Drs transcript level was comparable to the control with RNAi knockdown of Exp5. Here, TLR4 is linked to infection.