The regression analysis detected APACHE II score at admission (OR 1.305, 95% CI 1.079–1.578, P = 0.006), percentage of HLA-DR-expressing CD14+ monocytes on D1 (OR 0.923, 95% CI 0.869–0.981, P = 0.01), and percentage of PD-L1-expressing CD14+ monocytes on D1 (OR 1.098, 95% CI 1.005–1.200, P = 0.036) as independent significant predictors of IC in patients with AP. The gene discussed is CD274; the disease is alkaline phosphatase measurement.