These results appear discordant to the large population ADAGIO-lipids trial that showed weight loss and a decrease in ALT with rimonabant [25], and another trial showing weight loss was associated with a reduction in liver fat [26]; however, the first was a specific population with an atherogenic lipid profile and established fatty liver infiltration and the second trial was specifically in metabolic syndrome patients with demonstrable increased liver fat, and neither population was representative of the PCOS subjects here who had a normal liver ultrasound. The gene discussed is GPT; the disease is metabolic syndrome.