SMARCB1 and cancer: Furthermore, loss of function of SNF5, a member of SWI/SNF family, results in enhanced susceptibility to multiple early childhood cancers, mediated by elevated expression of the polycomb gene EZH2 (Enhancer of Zeste 2 Polycomb Repressive Complex 2 Subunit), resulting in increased H3K27me3 and cell cycle progression [63,64,65].