Interestingly the mechanism of MYC regulation mediated by lncRNAs working in cis is not limited to the MYC gene but was found associated also to the MYC homolog gene MYCN. Amplification of the genomic DNA region containing the MYCN oncogene is a recurrent event in almost one fourth of all human neuroblastomas [72]. This evidence concerns the gene MYCN and neuroblastoma.