Ig-domains of PECAM1 was required for the migration of monocytes through endothelial cells joint [22] and THY-1 mediates the adhesion of granulocytes and monocytes to the activated endothelial cells and this interaction has an essential role in the control of the migration of granulocytes and monocytes from blood into the tissues during inflammation or infection [23]. The gene discussed is PECAM1; the disease is infection.