To test the role of these PRR pathways, we utilized a model of cutaneous infection using a bioluminescent S. aureus strain (Xen36) to track the infection over time, as bioluminescence directly correlates with viability and bacterial numbers [43] and a similar bioluminescent S. aureus was used to show the importance of MyD88 in cutaneous infection with S. aureus [3]. The gene discussed is MYD88; the disease is infection.