IFNL3 and cryohydrocytosis: The immune system plays a central role in the therapeutic response and in the appearance of various disorders associated with CHC [7,8], and several genome-wide association studies have revealed the strong association of IL-28B rs12979860 polymorphism with the attainment of sustained virological response (SVR) in patients treated with the conventional antiviral therapy (pegylated-interferon and ribavirin) [9–11].