Indeed, a prospective cohort study has shown that lower NT-proBNP values were associated with higher risk of incident type diabetes over a 12-years follow-up period, independently of confounders and risk factors [11] and a common genetic BNP variant (rs198389), which results in a 20% increase in plasma BNP levels, was found associated with a 15% reduced risk of diabetes [12]. The gene discussed is NPPB; the disease is diabetes mellitus.