Meanwhile, on the basic of PMPs, we selected NF-κB specific inhibitor (JSH-23) to treat RA-FLSs, and the results suggested that not only the migration Migration capacity was limited, but also the levels of p-IκB, p-NF-κB and MMP1 were decreased, indicating that the alteration of MMP1 was induced by PMPs possibly through activating NF-κB signaling. The gene discussed is NFKB1; the disease is rheumatoid arthritis.