As shown in Fig 6C, transwell migration assay proved that PD98059 could inhibit migration of RA-FLSs, and data from Fig 6D–6F showed PD98059 suppressed the expression of p-Erk, p-IκB, p-NF-κB and MMP1 induced by PMPs. The gene discussed is NFKB1; the disease is rheumatoid arthritis.