The potential role of PGF2 epimers in NSCLC biology is not well characterized, but given their role in promoting endometrial tumorigenesis it is certainly plausible these molecules have similar effects in NSCLC, and prior genetic studies have identified AKR1C3 as associating with bladder and lung cancer risk [62, 63]. This evidence concerns the gene AKR1C3 and lung carcinoma.