Initial associations examined using the Kaplan-Meier estimator indicated that none of the rare variants in eicosanoid metabolism genes were associated with differences in NSCLC survival, but the presence of the interaction between ALOX15B and sex suggested the effect of rare variants in ALOX15B on prognosis differs by sex (S5 Table). This evidence concerns the gene ALOX15B and non-small cell lung carcinoma.