Data from this nationwide cross-sectional study revealed an independent inverse association between the insulin resistance, which was presented as the HOMA-IR and serum insulin level, and the BMD of the total hip, femoral neck, femoral trochanter, femoral intertrochanter, and lumbar spine in 2,750 Korean males and females aged 25–35 years, who are expected to exhibit near peak bone mass after adjusting for possible confounders in a multivariate linear regression analysis. Here, INS is linked to Insulin resistance.