Along with this, upregulation of SOCS genes and differential expression of genes involved in apoptotic pathways such as CASP1, CASP4, CASP8, BCL3, BCL6, BCL9, BAX, BIRC2 and BIRC3 indicates signalling to check the uncontrolled immune response during progression of infection [30]. This evidence concerns the gene CASP1 and infection.