Epigallocatechin-3-gallate (EGCG) is an abundant polyphenol in green tea extract, which possesses antioxidant, anti-inflammatory and antitumorigenic properties,22, 23, 24, 25, 26 and also a known inhibitor of STAT1.21, 27 Studies have shown beneficial effects of EGCG in treating diabetes, cancer, neurodegenerative disorders, cardiovascular disease and obesity.28, 29, 30, 31 Our interest in EGCG stems from the fact that it provides an orally effective STAT1 inhibitor with anticancer properties, which could complement the overall therapeutic benefits of cisplatin. The gene discussed is STAT1; the disease is obesity due to melanocortin 4 receptor deficiency.