RIPK3 and pancreatitis: However, neither Rip1 nor Rip3 is required for apoptosis execution.18 As mentioned in the Introduction, the contribution of Rip3 to caerulein-induced pancreatitis is highly controversial as it is in other disease models.13, 17, 18, 37 In Atg7Δpan mice, removal of Rip3 accelerated signs of pancreatitis, diabetes and reduced mortality rates.