However, neither Rip1 nor Rip3 is required for apoptosis execution.18 As mentioned in the Introduction, the contribution of Rip3 to caerulein-induced pancreatitis is highly controversial as it is in other disease models.13, 17, 18, 37 In Atg7Δpan mice, removal of Rip3 accelerated signs of pancreatitis, diabetes and reduced mortality rates. The gene discussed is RIPK3; the disease is diabetes mellitus.