EYA2 and breast cancer: EYA2 is also involved in stimulation of EMT, a process important for cancer cell migration, invasion, and metastasis.37 The EYA2 gene is hypomethylated in lung cancer cells, resulting in EYA2 overexpression.36 We showed that miR-338-3p directly inhibited EYA2 expression at the post-transcriptional level in cultured cancer cells and its expression negatively correlated with EYA2 expression in breast cancer patients.