miRNAs participate in many biological processes, such as cell proliferation, invasion, metastasis, and apoptosis.13 Recently, EGFR has been shown to promote prostate cancer bone metastasis by decreasing the expression of miR-1, a tumor suppressor, and increasing the expression of TWIST1, an oncogenic gene.14 However, how EGFR promotes cancer metastasis to lungs through microRNAs is unknown. This evidence concerns the gene EGFR and prostate cancer.