EYA2 and cancer: Downregulation of miR-338-3p leads to breast tumor growth and lung metastasis by activating eye absent 2 (EYA2), a member of Eya family that is implicated in cancer cell growth and metastasis.16, 17 Clinically, miR-338-3p negatively correlates with the expression of EGFR and EYA2, and EGFR status positively associates with EYA2 expression.