miRNAs participate in many biological processes, such as cell proliferation, invasion, metastasis, and apoptosis.13 Recently, EGFR has been shown to promote prostate cancer bone metastasis by decreasing the expression of miR-1, a tumor suppressor, and increasing the expression of TWIST1, an oncogenic gene.14 However, how EGFR promotes cancer metastasis to lungs through microRNAs is unknown. The gene discussed is EGFR; the disease is Familial prostate cancer.