There are several kinds of drugs against EGFR, including EGFR tyrosine kinase inhibitors (e.g. gefitinib) and EGFR monoclonal antibody (e.g., cetuximab).39, 40, 41 Although targeted therapy has benefitted many breast cancer patients, the combination therapy is still recommended for treatment of recurrent and metastatic patients. The gene discussed is EGFR; the disease is breast cancer.