CD34 and acute myeloid leukemia: As shown in Figure 4a, TP53mut AML CD34+ cells (n=5, Supplementary Table S3) were significantly less sensitive at 5, 10 or 20 μM HCQ compared with TP53wt cells (20 μM HCQ, 71.8.±9.8% versus 23.0±3.1% surviving cells, respectively, P<0.0001).