In addition, higher expression of the autophagy genes Beclin-1 and MAP1LC3A and the autophagy regulator FOXO3A was observed in ROSlow AML CD34+ cells compared with the ROShigh CD34+ cells (Figure 6c).30, 31 In contrast, expression of other key autophagy genes and major ROS scavengers such as SOD1, SOD2 and Catalase was comparable between both fractions (data not shown). Here, SOD1 is linked to acute myeloid leukemia.