These results are of interest since a previous study has shown that ROSlow AML CD34+ cells are enriched for LSCs.29 Similarly, murine ROSlow HSPC are enriched for stem cells.32 In the studied AMLs, the autophagy flux was most pronounced in adverse-risk group with complex cytogenetic abnormalities thath are frequently associated with TP53 mutations. Here, TP53 is linked to acute myeloid leukemia.