SOD2 and acute myeloid leukemia: In addition, higher expression of the autophagy genes Beclin-1 and MAP1LC3A and the autophagy regulator FOXO3A was observed in ROSlow AML CD34+ cells compared with the ROShigh CD34+ cells (Figure 6c).30, 31 In contrast, expression of other key autophagy genes and major ROS scavengers such as SOD1, SOD2 and Catalase was comparable between both fractions (data not shown).