FLG and Alzheimer disease: Recent genome-wide association studies on AD have identified three single-nucleotide polymorphisms (SNPs), rs479844 (OVOL1), rs3126085 (FLG), and rs11204971 (FLG), that are associated with AD in Japanese and Chinese patients.8, 9, 10, 11, 12, 13 The A allele of rs479844 (OVOL1) reportedly reduces AD risk.24 Furthermore, FLG mutation or dysfunction is a crucial factor in AD development.4, 5 Therefore, we can hypothesize that OVOL1 impairment results in the downregulation of FLG, thus potentiating the development of AD.