Cytokine signaling is known to activate NF-κB, and NF-κB signaling is known to promote cytokine production.28, 29 However, inhibition of NF-κB signaling alone is insufficient to increase sensitivity to cytotoxic drugs30 and was ineffective at diminishing cytokine production from breast cancer cells (Figure 3). Here, NFKB1 is linked to breast cancer.