NFKB1 and breast carcinoma: The NF-κB signaling pathway is known to play a critical role in the induction and maintenance of inflammatory cytokines.6, 7, 25, 26 Thus, consideration was given to the possibility that activation of NF-κB initiated by paclitaxel-induced supernatants enabled breast cancer cells to continually produce inflammatory cytokines, thereby forming an autocrine inflammatory forward-feedback loop that further promotes CSC enrichment.