CXCR1 and neoplasm: When the tumor reached a mean diameter of 4 mm after 15 days of implantation, mice were randomized into 4 groups and injected intraperitoneally with vehicle, paclitaxel (10 mg/kg on days 15, 20 and 25), IL8 receptor CXCR1/2 inhibitor reparixin (25 mg/kg once every other day starting from days 26 for 10 days), or paclitaxel following by reparixin (Figure 6a).