REN and familial dilated cardiomyopathy: Diabetic cardiomyopathy (DCM), which is defined as myocardial dysfunction occurring in the absence of coronary artery disease and hypertension, carries a substantial risk for the subsequent development of heart failure.1 There is growing evidence that oxidative stress, inflammation, mitochondrial dysfunction, impaired calcium handling, renin-angiotensin system activation, cardiomyocyte apoptosis are involved in the pathogenesis of DCM.2