Moreover, SDC-4 inhibition suppressed FGF-induced cell cycle progression in RPE cells, indicating that SDC-4 is also critical for the development other intraocular fibrotic disorders such as proliferative vitreoretinopathy (PVR), which is resulted from similar pathological processes including proliferation, migration, and EMT of the retinal pigment epithelium.50 This evidence concerns the gene SDC4 and CAPN5-related vitreoretinopathy.