For example, SDC-4 expression is upregulated in testicular germ cell tumor and osteosarcoma, and is correlated with the incidence of distant metastasis.62, 63 SDC-4 overexpression is also highly associated with progression of breast cancer.64 Therefore, SDC-4 can be a potential biomarker and therapeutic target for cancer. This evidence concerns the gene SDC4 and breast carcinoma.